A Boolean network model of human gonadal sex determination
نویسندگان
چکیده
منابع مشابه
I-17: The Mechanism of Gonadal Sex Determination
Background In mammals, a single exon gene SRY on the Y-chromosome is activated in the XY gonadal primordium and initiates a cascade of molecular and morphological events leading to testicular differentiation. SRY-encoded protein (SRY) is a transcription factor harboring a HMG-box DNAbinding motif that upregulates SOX9, which encodes another transcription factor sharing the DNA binding motif wit...
متن کاملSex determination and gonadal development in mammals.
Arguably the most defining moment in our lives is fertilization, the point at which we inherit either an X or a Y chromosome from our father. The profoundly different journeys of male and female life are thus decided by a genetic coin toss. These differences begin to unfold during fetal development, when the Y-chromosomal Sry ("sex-determining region Y") gene is activated in males and acts as a...
متن کاملGonadal asymmetry and sex determination in birds.
Although vertebrates display a superficial bilateral symmetry, most internal organs develop and locate with a consistent left:right asymmetry. There is still considerable debate as to when this process actually begins, but it seems that, at least for some species, the initial steps occur at a very early stage of development. In recent years, a number of model systems, including the chick embryo...
متن کاملI-40: The Genetic Complexities of Human Sex-Determination
Background - MaterialsAndMethods N;Results N;Conclusion N;
متن کاملChanges in gonadal gene network by exogenous ligands in temperature-dependent sex determination.
We examined the expression of candidate sex-determining genes in the red-eared slider turtle (Trachemys scripta) during the temperature-sensitive period (TSP). Aromatase and Rspo1 were used as markers of ovarian differentiation and Sox9 was used as a marker of testicular differentiation. Eggs were incubated at a male-producing temperature (26 °C or MPT) and a female-producing temperature (31 °C...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Theoretical Biology and Medical Modelling
سال: 2015
ISSN: 1742-4682
DOI: 10.1186/s12976-015-0023-0